Inter are in crisis and rely on Ivan Perisic and Mauro Icardi in a very difficult trip to Gervinho’s surprising giant-killers Parma.
It kicks off at the Stadio Tardini at 19.30 GMT.
Luciano Spalletti is under immense pressure amid reports he could be fired, as Inter have not scored a single Serie A goal in 2019, picking up just one point against Sassuolo with defeats to Torino and Bologna.
Borja Valero and Sime Vrsaljko are injured, with Matteo Politano suspended, so Radja Nainggolan returns to the starting XI with Perisic behind Icardi.
Their captain and centre-forward has not scored in six Serie A games, his longest drought ever in an Inter jersey.
Joao Mario completes the midfield with Matias Vecino and Marcelo Brozovic.
Parma, on the other hand, are fired up after their comeback from 3-1 down to hold Juventus 3-3 in Turin last week.
Alberto Grassi, Francisco Sierralta, Federico Dimarco, Brazao and Schiappacasse are unavailable, but Leo Stulac is again benched in favour of Matteo Scozzarella.
Gervinho is the danger man with centre-forward Roberto Inglese and Luca Siligardi.
Parma won 1-0 at San Siro, but haven’t beaten Inter home and away in a single Serie A campaign since 1998-99.
The Nerazzurri have a notoriously poor record at the Tardini, winning only four of their 24 top flight trips here.
Parma: Sepe; Iacoponi, Bruno Alves, Bastoni, Gagliolo; Kucka, Scozzarella, Barillà; Gervinho, Inglese, Siligardi
Parma bench: Frattali, Bagheria, Stulac, Diakhate, Ceravolo, Machin, Gobbi, Gazzola, Rigoni, Dezi, Biabiany, Sprocati
Inter: Handanovic; D'Ambrosio, Skriniar, De Vrij, Asamoah; Vecino, Brozovic, Joao Mario; Nainggolan, Perisic; Icardi
Inter bench: Padelli, Gagliardini, Lautaro Martinez, Ranocchia, Cedric, Miranda, Dalbert, Candreva