Bologna have been revitalised under Sinisa Mihajlovic and hope to climb out of the bottom three as they host Antonio Sanabria’s Genoa.
It kicks off at the Stadio Dall’Ara at 11.30 GMT.
Mihajlovic could not have asked for a better debut when replacing Pippo Inzaghi, as he took Bologna to their first away victory in over a year, conquering Inter 1-0 at San Siro.
Federico Santander is not 100 per cent fit, so Mattia Destro is given a rare start as a centre-forward, supported by Rodrigo Palacio and January signing from Torino Simone Edera.
Federico Mattiello and Filip Helander return to the defence from suspension, but Lyanco and Riccardo Orsolini are injured.
Genoa have also improved after a change of management, drawing with Sassuolo and beating Empoli since Cesare Prandelli took over.
Cristian Romero sits out a one-match ban, with Luca Mazzitelli, Oscar Hiljemark and Andrea Favilli on the treatment table, so Koray Gunter gets the nod in the back four.
Sanabria has made a huge impression since coming in for Krzysztof Piatek, scoring in each of his two appearances in a Grifone jersey.
Expect a strong start, because nobody has conceded more first half goals than Genoa this season (22) and Bologna scored 10 out of a total 17 goals in the same period.
Bologna: Skorupski; Mbaye, Danilo, Gonzalez, Mattiello; Poli, Pulgar, Soriano; Palacio, Destro, Edera
Genoa: Radu; Biraschi, Zukanovic, Gunter, Criscito; Lerager, Radovanovic, Rolon, Lazovic; Kouame, Sanabria
Watch Serie A live in the UK on Premier Sports and get your first month free, visit https://www.premiersports.com/football/eleven-sports-customer.html