Milan must beat Cagliari to recapture fourth place, so hope Krzysztof Piatek and Lucas Paquetá continue their fine recent form.
It kicks off at San Siro at 19.30 GMT.
The pressure is on, because Roma, Lazio and Atalanta all won their matches, allowing them to leap into joint fourth place.
If Gennaro Gattuso’s men don’t get the victory this evening, they will suddenly find themselves sliding from fourth to seventh.
Milan are without the usual suspects Cristian Zapata, Mattia Caldara, Pepe Reina, Jack Bonaventura and Ivan Strinic, but Lucas Biglia is back on the bench for the first time since October.
Piatek aims to continue his remarkable scoring streak and Paquetá maintains his run of starting every single match since he arrived in the January transfer window.
Suso and under-fire Hakan Calhanoglu complete the trident attack.
Cagliari are struggling just above the relegation zone and made the trip without Cyril Thereau, Lucas Castro, Valter Birsa, Ragnar Klavan or Fabrizio Cacciatore.
Alberto Cerri is not 100 per cent fit either, so Joao Pedro and Leonardo Pavoletti are supported by Nicolò Barella.
Luca Pellegrini, on loan from Roma, gets his first start at left-back.
Cagliari haven’t won away at Milan since May 1997 and lost each of the last 13 Serie A visits.
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Bakayoko, Paquetá; Suso, Piatek, Calhanoglu
Milan bench: A Donnarumma, Plizzari, Abate, Conti, Laxalt, Biglia, Bertolacci, Montolivo, Mauri, Cutrone, Castillejo, Borini
Cagliari: Cragno; Srna, Ceppitelli, Pisacane, Pellegrini; Faragò, Padoin, Ionita; Barella; Joao Pedro, Pavoletti
Cagliari bench: Aresti, Rafael, Leverbe, Lykogiannis, Romagna, Bradaric, Cigarini, Deiola, Oliva, Cerri, Despodov, Doratiotto