Lazio have Ciro Immobile and Sergej Milinkovic-Savic back in the starting XI as they try to overturn a 1-0 first leg deficit away to Sevilla.
The second leg in the Round of 32 kicks off at the Estadio Sanchez Pizjuan at 17.00 GMT.
You can follow the build-up and action to this game and Atletico Madrid v Juventus on the LIVEBLOG.
Lazio have Ciro Immobile and Sergej Milinkovic-Savic back in the starting XI as they try to overturn a 1-0 first leg deficit away to Sevilla.
The second leg in the Round of 32 kicks off at the Estadio Sanchez Pizjuan at 17.00 GMT.
You can follow the build-up and action to this game and Atletico Madrid v Juventus on the LIVEBLOG.
Sevilla were fortunate to grab a 1-0 result at the Stadio Olimpico, as Lazio were decimated by injuries and lost several more players during the 90 minutes, as well as forcing a Simon Kjaer goal-line clearance.
Immobile and Milinkovic-Savic are both back in the side, but Luis Alberto, Luiz Felipe, Bastos, Wallace and Valon Berisha are still side-lined.
Lucas Leiva and Marco Parolo are not 100 per cent fit and therefore start on the bench, so Danilo Cataldi and Milan Badelj go in midfield.
Felipe Caicedo is chosen as the partner for ex-Sevilla striker Immobile rather than Joaquin Correa.
Sevilla are still missing Maxime Gonalons, Nolito, Joris Gnagnon and Aleix Vidal, while Ever Banega joins Maximilian Wober on the list of suspended players.
Former Milan star Andre Silva leads the way with first leg goalscorer Wissam Ben Yedder, while ex-Palermo man Franco Vazquez is the creative midfield force.
Milinkovic-Savic, Stefan Radu and Francesco Acerbi are all one booking away from suspension.
Sevilla: Vaclik; Mercado, Kjaer, Sergi Gomez; Navas,, Roque Mesa, Vazquez, Escudero; Andre Silva, Ben Yedder
Sevilla bench: Soriano, Arana, Promes, Rog, Amadou, Gil, Munir
Lazio: Strakosha; Patric, Acerbi, Radu; Marusic, Cataldi, Badelj, Milinkovic-Savic, Lulic; Caicedo, Immobile
Sevilla bench: Proto, Guerrieri, Zitelli, Durmisi, Parolo, Romulo, Leiva, Correa
Ref: Taylor (ENG)