Join us for all the build-up and action as it happens from Empoli-Parma, Milan v Sassuolo and the spectacular Derby della Capitale between Lazio and Roma.
We begin at 14.00 GMT at the Stadio Castellani, where Empoli have stuttered more than Parma since promotion from Serie B, but precious points are up for grabs.
At 17.00 GMT, around 60,000 people are expected at San Siro to see Gennaro Gattuso’s Milan take on Sassuolo, as a victory would see them leapfrog rivals Inter into third place.
That’s because the Nerazzurri lost 2-1 in Cagliari last night and the race for a Champions League berth is hotting up.
Roma and Lazio are also hoping to take advantage of Inter’s slide, so there is more than just local pride at stake in the Derby della Capitale.
The Stadio Olimpico lights up at 19.30 GMT for this legendary fixture, one of the most passionate derbies in the world.
All games will halt at the 13th minute this weekend to remember Davide Astori, a year on from the Fiorentina captain and Italy international’s death.