Milan know with a victory over struggling Sassuolo, they can leapfrog Inter into third place, so rely on Krzysztof Piatek, Suso and Lucas Paqueta.
It kicks off at San Siro at 17.00 GMT with over 60,000 expected in the stands.
Inter lost 2-1 to Cagliari last night, meaning a win would allow the Rossoneri to surpass their city rivals and leap into third place, something they have not experienced at this stage of the season since 2012-13.
Cristian Zapata, Mattia Caldara (who played 45 minutes for the youth team today) and Giacomo Bonaventura are still out of action, but Suso returns to the trident attack after his suspension.
Hakan Calhanoglu is also back in the starting XI after he was rested in Tuesday’s 0-0 Coppa Italia semi-final draw with Lazio.
There were some concerns over Franck Kessie with a knock to the thigh, but he has recovered and takes his usual slot in midfield.
Piatek has 26 goals in 28 competitive games this season, but the 0-0 Coppa Italia draw was the first time he failed to find the net in the Milan starting XI.
Sassuolo’s form is sliding lately and they make this trip without suspended midfielder Alfred Duncan, while Marlon is injured.
Domenico Berardi is available again after his suspension and he loves this fixture, having scored eight goals in just nine previous games against Milan.
Khouma Babacar is benched again, using Filip Djuricic and Jeremie Boga in the trident attack, while it’s a return to San Siro for ex-Milan youth talent Manuel Locatelli.
Sassuolo have a traditionally tricky time against Milan, managing just one point from their last five Serie A meetings, with the most recent victory in March 2016.
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessié, Bakayoko, Paqueta, Suso, Piatek, Calhanoglu
Milan bench: Reina, A Donnarumma, Castillejo, Borini, Conti, Bertolacci, Montolivo, Abate, Biglia, Strinic, Cutrone, Laxalt
Sassuolo: Consigli; Lirola, Demiral, Ferrari, Peluso; Locatelli, Sensi, Magnanelli; Berardi, Djuricic, Boga
Sassuolo bench: Pegolo, Lemos, Da Silva, Matri, Scamaccia, Sernicola, Odgaard, Magnani, Khouma, Di Francesco, Bourabia, Adjapong