Inter need to beat SPAL in order to stay in the top four and keep within touching distance of Milan, but must completely revamp.
It kicks off at 14.00 GMT, you can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
The Nerazzurri are under pressure from all sides, as they must prepare for the Europa League showdown with Eintracht Frankfurt next Thursday after their 0-0 draw in Germany, but also keep their top four status intact ahead of next Sunday’s Milan Derby.
Mauro Icardi is still unavailable, as Luciano Spalletti confirmed the medics gave him the all-clear, but the striker replied: “No, I still feel pain. I’ll tell you when I am ready to play.”
He has not played or even trained with the team since he was stripped of the captaincy on February 13.
Radja Nainggolan is injured, with Matias Vecino suspended, while Ivan Perisic and Keita Balde Diao are not 100 per cent fit.
It means Lautaro Martinez has to again do overtime in attack, despite being one yellow card away from a Serie A ban.
He is suspended for next week’s Europa League clash with Eintracht Frankfurt.
Milan Skriniar and Danilo D’Ambrosio are rested, as a booking today would rule them out of the Milan Derby.
Instead, Kwadwo Asamoah is pushed into a more advanced role with Matteo Politano and Joao Mario to support Lautaro, with rare starts for Cedric Soares, Dalbert and Roberto Gagliardini.
SPAL are hovering five points above the relegation zone and have really suffered since star man Manuel Lazzari’s injury.
Alessandro Murgia is also out of action with a bout of flu, and defender Thiago Cionek suspended, so Mattia Valoti steps in on the right flank.
Sergio Floccari is chosen rather than Mirco Antenucci to partner Andrea Petagna.
Inter: Handanovic; Cedric, Miranda, De Vrij, Dalbert; Gagliardini, Brozovic; Politano, Joao Mario, Asamoah; Lautaro Martinez
SPAL: Viviano; Bonifazi, Vicari, Felipe; Valoti, Kurtic, Schiattarella, Missiroli, Fares; Floccari, Petagna