Joao Miranda will need surgery to reduce a fractured nose, while Marcelo Brozovic is in doubt against Eintracht and Milan with a muscular issue.
The Nerazzurri earned a 2-0 victory over SPAL at San Siro this afternoon, but it came at a cost.
Miranda was caught in the face by a flailing Andrea Petagna arm in the opening minutes and went off at half-time after receiving treatment several times.
Tests have now shown Miranda sustained a fractured nose with dislocated septum.
The Brazil international is expected to have surgery to reduce the fracture over the next 48 hours.
Inter also lost Brozovic to a muscular problem, although that will need a little more time before tests can show the extent of the damage.
However, both players have a real race against time to be fit for not only Thursday’s Europa League clash with Eintracht Frankfurt, but also next weekend’s Derby della Madonnina.