Juventus have as many as nine players missing for their game against Cagliari in Serie A on Tuesday.
Mattia Perin, Leonardo Spinazzola, Mario Mandzukic and Paulo Dybala join Andrea Barzagli, Juan Cuadrado, Sami Khedira, Douglas Costa and Cristiano Ronaldo on the sidelines for Juve.
To make up for the lack of numbers, Coach Max Allegri has promoted trio Grigoris Kastanos, Hans Nicolussi Caviglia and ex-Arsenal striker Stephy Mavididi from the Under-23 team.
However, the coast is clear for Italy sensation Moise Kean to lead the line in Sardinia after his winner against Empoli at the weekend.
Juve squad to face Cagliari: Szczesny, Pinsoglio, Del Favero; De Sciglio, Chiellini, Caceres, Alex Sandro, Bonucci, Cancelo, Rugani; Pjanic, Matuidi, Emre Can, Bentancur, Kastanos, Nicolussi Caviglia; Kean, Bernardeschi, Mavididi