Mauro Icardi and Ivan Perisic lead the way for Inter, this time at San Siro, but Atalanta use Papu Gomez and Josip Ilicic to replace Duvan Zapata.
It kicks off at 17.00 UK time (16.00 GMT).
With Milan losing to Juventus on Saturday, a win would catapult Atalanta into the fourth and final Champions League spot, while the Nerazzurri are already in third and can break clear of the chasing pack.
However, Gian Piero Gasperini has to do without suspended star striker Duvan Zapata, who scored 20 Serie A goals this season.
Rather than opt for Musa Barrow, who has a great deal of pace, but little physicality, Gasp has readjusted with a False 9 approach.
Captain Papu Gomez and trequartista Josip Ilicic are expected to rotate in the role of centre-forward to keep the Inter defenders on their toes, with Mario Pasalic in support.
Rafael Toloi is still out of action with an injury in the back three, but it’s Andrea Masiello who drops to the bench with Timothy Castagne preferred to Robin Gosens.
Inter are without injured Lautaro Martinez, Stefan de Vrij and Sime Vrsaljko, but Icardi returned with a bang in the midweek 4-0 victory at Genoa.
Maurito earned and converted a penalty, then provided the assist for Ivan Perisic, but this is his first time facing the San Siro crowd since he was stripped of the captaincy on February 13 and negotiated a comeback to training via a lawyer.
Roberto Gagliardini starts against his former club, a nice way to celebrate his birthday, but Inter move to 4-3-3 with Radja Nainggolan rested.
Inter: Handanovic; D’Ambrosio, Miranda, Skriniar, Asamoah; Gagliardini, Brozovic, Vecino; Politano, Icardi, Perisic
Inter bench: Padelli, Ranocchia, Cedric, Dalbert, Borja Valero, Nainggolan, Joao Mario, Candreva, Keita Baldé
Atalanta: Gollini; Mancini, Djimsiti, Palomino; Hateboer, De Roon, Freuler, Castagne; Pasalic, Ilicic; Gomez
Atalanta bench: Berisha, Rossi, Masiello, Ibañez, Reca, Gosens, Pessina, Kulusevski, Piccoli, Barrow
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