There are reports of 120 Juventus fans arrested in Amsterdam, while Ajax supporters clashed with riot police in separate incidents.
The Champions League quarter-final first leg kicks off at 20.00 UK time (19.00 GMT).
There have been several incidents building up to the game, as fans begin to make their way into the Johan Cruijff Arena.
Italian Deputy Prime Minister and Minister for the Interior Matteo Salvini confirmed via a Facebook live video that there had been “around 120 arrests because people were found carrying objects that were not exactly appropriate for a trip to the stadium.
“Football is beautiful, sport is beautiful, but only with clean hands and a clean face, without creating trouble, so be good.”
Those arrests found knives, screwdrivers, sticks and pepper spray in searches on fans in Amsterdam city centre.
Separately to that situation, dozens of Ajax hooligans tried to attack the police just outside the stadium and officers responded with horseback charges, tear gas and water cannon.
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/