Milan are expected to stick with Fabio Borini and Krzysztof Piatek in attack, while Lazio opt for Joaquin Correa alongside Ciro Immobile.
It kicks off at San Siro at 19.30 UK time (18.30 GMT), click here for a match preview.
Both teams are facing injury problems as they go into this head-to-head for the fourth and final Champions League spot.
Gennaro Gattuso misses Lucas Paqueta, Gianluigi Donnarumma and Jack Bonaventura, while Andrea Conti is likely to be on the bench.
Milan are expected to stick with Fabio Borini and Krzysztof Piatek in attack, while Lazio opt for Joaquin Correa alongside Ciro Immobile.
It kicks off at San Siro at 19.30 UK time (18.30 GMT), click here for a match preview.
Both teams are facing injury problems as they go into this head-to-head for the fourth and final Champions League spot.
Gennaro Gattuso misses Lucas Paqueta, Gianluigi Donnarumma and Jack Bonaventura, while Andrea Conti is likely to be on the bench.
Cristian Zapata is back from his lengthy lay-off and could step into central defence rather than Mateo Musacchio.
Franck Kessie should win the midfield battle with ex-Lazio star Lucas Biglia, while a deeper Hakan Calhanoglu role means Borini and Suso flanking Piatek.
Lazio have numerous issues to deal with, as Milan Badelj sits out a ban, with Stefan Radu, Adam Marusic, Valon Berisha and Jordan Lukaku injured.
Romulo has been tested out in training on the right flank of a 3-5-2 formation, with Senad Lulic on the left, allowing Sergej Milinkovic-Savic and Luis Alberto to surround Lucas Leiva.
Correa is the hot favourite to partner Immobile upfront, sending Felipe Caicedo to the bench.
Probable line-ups
Milan: Reina; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Bakayoko, Calhanoglu; Suso, Piatek, Borini
Lazio: Strakosha; Luiz Felipe, Acerbi, Bastos; Romulo, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Correa, Immobile