Napoli take no chances against bottom of the table Chievo, starting Arkadiusz Milik, Dries Mertens and Lorenzo Insigne together.
It kicks off at the Stadio Bentegodi at 17.00 UK time (16.00 GMT).
There is plenty at stake here, because Chievo will be automatically relegated if they don’t win this game.
If Napoli don’t get the victory, it will hand the Scudetto mathematically to Juventus.
The Partenopei were beaten 2-0 by Arsenal in the Europa League quarter-final on Thursday and the second leg is next week, but Carlo Ancelotti is not tempted into mass squad rotation.
Instead, he uses all his strikers simultaneously, perhaps preparing this approach for the return game against the Gunners.
Vlad Chiriches is given a run-out in central defence, with Allan, Mario Rui and Alex Meret rested.
Chievo have lost three on the bounce and are preparing for life in Serie B.
Mattia Bani is suspended, replaced by Bostjan Cesar, with teenager Vignato joining Mariusz Stepinski and Riccardo Meggiorini in attack.
Emanuele Giaccherini is eager to make a good impression on his old club.
Napoli: Ospina, Hysaj, Chiriches, Koulibaly, Ghoulam; Callejon, Zielinski, Fabian Ruiz, Insigne; Mertens, Milik
Chievo: Sorrentino; Depaoli, Cesar, Andreolli, Barba; Giaccherini, Diousse, Hetemaj; Vignato; Stepinski, Meggiorini
Ref: La Penna