Lazio need a victory in Sardinia to keep their European ambitions going, but start Silvio Proto in goal against unpredictable Cagliari.
It kicks off at the Sardegna Arena at 17.00 UK time (16.00 GMT).
Simone Inzaghi’s men might be inclined to start focusing all their energy on the Coppa Italia Final against Atalanta on May 15, as that could also be their best route into the Europa League group phase.
Dreams of a top four finish evaporated after a run of poor Serie A results, culminating in last week’s 3-1 home defeat to Atalanta.
Thomas Strakosha has joined Sergej Milinkovic-Savic, Patric, Valon Berisha and Jordan Lukaku on the treatment table, meaning Belgian goalkeeper Proto makes his Serie A debut.
Since joining the club from Olympiacos last summer, Proto has only made four appearances for Lazio, all in the Europa League.
It is a fine birthday gift for the veteran, who turns 36 later this month.
In the same vein, Ciro Immobile and Lucas Leiva are rested in favour of a Joaquin Correa-Felipe Caicedo partnership.
It’s one that has worked well before, most recently in the 2-1 victory away to Sampdoria.
Cagliari are now safely ensconced in mid-table, but also still furious with the decision to award a stoppage-time penalty to Napoli based on the tiniest of margins.
Artur Ionita was sent off in that defeat and is suspended, with Paolo Faragò out for six months following hip surgery and Luca Ceppitelli also injured for this game.
Joao Pedro returns to support Leonardo Pavoletti with aid from Nicolò Barella.
Cagliari: Cragno; Cacciatore, Klavan, Romagna, Pellegrini; Deiola, Cigarini, Padoin; Barella; Joao Pedro, Pavoletti
Lazio: Proto; Luiz Felipe, Acerbi, Radu; Marusic, Parolo, Badelj, Luis Alberto, Lulic; Correa, Caicedo