Milan absolutely must win to keep within three points of Atalanta and the Champions League places as they visit Vincenzo Montella’s struggling Fiorentina.
It kicks off at the Stadio Artemio Franchi at 19.30 UK time (18.30 GMT).
Atalanta beat Genoa 2-1 this afternoon, meaning Milan have to get the victory or can practically kiss their Champions League ambitions goodbye.
Lucas Paqueta begins his three-match ban for slapping the referee’s hand away during a fiery 2-1 win over Bologna, so the season is effectively over for the Brazilian.
Lucas Biglia limped off during the game, so joins Davide Calabria, Mattia Caldara, Ivan Strinic and Giacomo Bonaventura on the absentee list.
Tiemoue Bakayoko is welcomed back into the fold following his ugly touchline row with Coach Gennaro Gattuso, as he warmed up too slowly against Bologna and infuriated the tactician, so they then exchanged words.
It seems as if the situation has been fully resolved, as Bakayoko starts in midfield with Franck Kessie and Hakan Calhanoglu, the Turkey international able to play despite muscular issues.
Fabio Borini scored against Bologna and is given a starting spot in the trident with Suso and Krzysztof Piatek.
Alessio Romagnoli returns from suspension and is partnered in central defence by Mateo Musacchio rather than Cristian Zapata.
Fiorentina have nothing more to fight for, other than pride and technically Serie A safety, as they are not yet mathematically safe from the threat of relegation.
It has been an awful campaign for the Tuscans, who parted company with Coach Stefano Pioli and brought in Vincenzo Montella last month.
Milan had fired Montella in November 2017 to promote Gattuso from the Milan youth team, although it looks as if Rino could be heading for the exit too this summer.
Jordan Veretout is suspended in midfield, with German Pezzella and Marko Pjaca injured, so Vitor Hugo and Bryan Dabo come in.
Kevin Mirallas again completes the trident attack with Luis Muriel and Federico Chiesa, leaving Giovanni Simeone on the bench.
Fiorentina will pay tribute to the 1968-69 Scudetto-winning team by having a parade of those players before kick-off to salute the fans and wear a special jersey with 50th anniversary patch on the sleeve.
Milan have won only one of their last seven top flight visits to the Stadio Franchi, 0-2 on March 26, 2014, drawing four and losing the other two.
Fiorentina are without a win in 11 rounds, putting together five draws and six defeats since a 4-1 victory away to SPAL on February 17. This is their longest negative streak within a single Serie A season since 12 from November 1989 to February 1990 (that was eight draws and four defeats).
If we include the Coppa Italia, then Fiorentina are winless in 13 matches, including a current streak of four consecutive defeats.
Fiorentina: Lafont; Laurini, Milenkovic, Vitor Hugo, Biraghi; Dabo, Edimilson Fernandes, Benassi; Chiesa, Muriel, Mirallas
Fiorentina bench: Terracciano, Brancolini, Antzoulas, Ceccherini, Ferrarini, Hancko, Norgaard, Gerson, Koffi, Montiel, Simeone, Vlahovic
Milan: G Donnarumma; Abate, Musacchio, Romagnoli, Rodriguez; Kessie, Bakayoko, Calhanoglu; Suso, Piatek, Borini
Milan bench: Reina, A Donnarumma, Zapata, Conti, Laxalt, Bertolacci, Mauri, Castillejo, Cutrone