Inter must win to keep some distance between them and chasing pack while Chievo have nothing to play except pride.
It kicks off at the Stadio Giuseppe Meazza at 20:00 (19:00 GMT).
The Nerazzurri are currently in fourth place with 63 points, just two behind Atalanta in third and they need the win to go back up into third.
The Biscione are unbeaten in their last six Serie A games, but have won just two of those, drawing the other four.
With Atalanta, Roma, Milan, and Torino all running out victorious this weekend the pressure is on the Beneamata to pick up the three points here.
Luciano Spalletti has selected Mauro Icardi rather than Lautaro Martinez to lead the way, while Cedric Soares and Borja Valero step in for suspended Marcelo Brozovic and Danilo D’Ambrosio.
Dutch centre-back Stefan de Vrij misses out through injury.
The Gialloblu on the other hand, are already relegated and will be only playing for pride, but as Coach Mimmo Di Carlo pointed out, his team always put in a performance against the big sides.
The Veronese club won their last away game when they beat Lazio 2-1 at the Stadio Olimpico, but unfortunately for them that was their only win on the road this season.
Di Carlo has said Sergio Pellissier, who scored an injury-time equaliser in the 1-1 draw with the Nerazzurri at the Bentegodi in December, will feature in his final game at San Siro.
However, it won’t be from the start.
Midfielder Assane Diousse is suspended, but Mattia Bani is in the starting XI.
Inter: Handanovic; Cedric, Skriniar, Miranda, Asamoah; Vecino, Borja Valero; Politano, Nainggolan, Perisic; Icardi
Inter bench: Padelli, Ranocchia, Dalbert, Gagliardini, Joao Mario, Candreva, Keita Baldé, Lautaro Martinez
Chievo: Semper; Tomovic, Cesar, Bani; Depaoli, Rigoni, Hetemaj, Leris; Vignato; Meggiorini, Grubac
Chievo bench: Seculin, Caprile, Andreolli, Frey, Karamoko, Ndrecka, Jaroszynski, Burruchaga, Piazon, Kiyine, Pucciarelli, Pellissier, Stepinski