Andrea Barzagli starts in what will be the final Juventus Stadium match for him and Coach Max Allegri, but Atalanta need points for the Champions League.
It kicks off at 19.30 UK time (18.30 GMT) and will also see Juve presented with their eighth consecutive Serie A trophy.
Barzagli is retiring at the age of 38, while Juventus announced on Friday that Allegri will not be the Coach next season, so there is a bittersweet atmosphere in Turin this evening.
Giorgio Chiellini, Sami Khedira, Douglas Costa and Mattia Perin are out injured.
Mario Mandzukic makes his return after a month out with a knee problem.
Atalanta need a win to ensure they keep hold of fourth place and could even leapfrog Inter into third, seeing as the Nerazzurri are away to Napoli tonight.
There is the risk of fatigue and low morale after Wednesday’s 2-0 Coppa Italia Final defeat to Lazio.
Jose Luis Palomino is suspended, with Rafael Toloi injured, so Hans Hateboer steps in to the defence.
Papu Gomez again supports Josip Ilicic and Duvan Zapata, with Robin Gosens on the left flank.
Juventus: Szczesny; Cancelo, Barzagli, Bonucci, Alex Sandro; Emre Can, Pjanic, Matuidi; Cuadrado, Dybala, Ronaldo
Atalanta: Gollini; Hateboer, Djimsiti, Masiello; Gosens, De Roon, Freuler, Castagne; Gomez; Ilicic, Duvan Zapata