Inter are expected to start Matteo Politano, Stefan de Vrij and Mauro Icardi in the showdown with relegation-threatened Empoli.
It kicks off at San Siro at 19.30 UK time (18.30 GMT), click here for a match preview.
Inter need a victory to be sure of a top four finish, although if Atalanta beat Sassuolo then it’ll only be enough for fourth due to an inferior head-to-head record.
Empoli know a win, or at least matching Genoa’s result with Fiorentina, will ensure they avoid relegation.
Luciano Spalletti has a full squad to choose from, as De Vrij has recovered from an injury that saw him miss games against Chievo and Napoli.
Matias Vecino is expected to step in for Roberto Gagliardini in midfield, with Politano also shaking off a knock to accompany Radja Nainggolan and Ivan Perisic.
Icardi is currently the favourite to lead the attack, but do not rule out Lautaro Martinez from taking his place.
Empoli have not been able to get Rade Krunic fit in time, so he is out of action along with Luca Antonelli, Antonino La Gumina, Kevin Diks and Lorenzo Polvani.
Domenico Maietta is the favourite to start in defence rather than Frederic Veseli, with Marko Pajac and Giovanni Di Lorenzo as wing-backs.
Afriyie Acquah, who scored in last week’s 4-1 win over Torino, is again in midfield to replace injured Krunic.
Francesco ‘Ciccio’ Caputo kept his training regime to a minimum over the last week to ensure he did not strain his muscles and is therefore able to start alongside Diego Farias.
Inter: Handanovic; D'Ambrosio, De Vrij, Skriniar, Asamoah; Vecino, Brozovic; Politano, Nainggolan, Perisic; Icardi
Inter bench: Padelli, Berni, Miranda, Ranocchia, Cedric, Dalbert, Gagliardini, Borja Valero, Joao Mario, Candreva, Keita Balde, Martinez
Empoli: Dragowski; Maietta, Silvestre, Dell'Orco; Di Lorenzo, Acquah, Bennacer, Traoré, Pajac; Caputo, Farias
Empoli bench: Provedel, Perucchini, Rasmussen, Nikolau, Veseli, Pasqual, Capezzi, Brighi, Salih Uçan, Oberlin, Mchedlidze