Lazio can rely on new signing Manuel Lazzari with a protective cast in their difficult trip to Eusebio Di Francesco’s new Sampdoria.
It kicks off at Marassi at 19.45 UK time (18.45 GMT).
There were fears Lazzari would miss both this season opener and the Derby della Capitale against Roma after fracturing a metacarpal bone in his hand during a friendly.
However, the former SPAL wing-back had surgery the very next day to stabilise the fracture and is able to start with the aid of a protective cast.
Jordan Lukaku and Wallace are injured, with Jony Rodriguez still waiting for his international transfer to come through following a row with Malaga.
Luiz Felipe gets the nod in defence rather than new buy Denis Vavro, while Lucas Leiva and Felipe Caicedo are only fit for the bench.
Sampdoria already played under Coach Di Francesco in last week’s Coppa Italia victory over Crotone, but Gonzalo Maroni was stretchered off with a sprained ankle.
Fabio Depaoli is suspended, while Gaston Ramirez and Jakub Jankto were both carrying knocks going into this game, so Rolando Vieira and Manolo Gabbiadini start.
Sampdoria: Audero; Bereszynski, Murillo, Colley, Murru; Linetty, Ekdal, Vieira; Gabbiadini, Quagliarella, Caprari
Lazio: Strakosha; Luiz Felipe, Acerbi, Radu; Lazzari, Milinkovic-Savic, Parolo, Luis Alberto, Lulic; Correa, Immobile