Inter look to Romelu Lukaku and Lautaro Martinez again in this trip to Cagliari, who transform their side with Robin Olsen, Radja Nainggolan and Marko Rog.
It kicks off at the Sardegna Arena at 19.45 UK time (18.45 GMT).
Antonio Conte started with a bang, thrashing Lecce 4-0 at San Siro with Lukaku scoring on his debut.
The Belgian is again partnered by Lautaro Martinez, with Antonio Candreva and Kwadwo Asamoah revitalised by the 3-5-2 formation.
Stefan de Vrij is out injured and Diego Godin only fit for the bench, so Andrea Ranocchia again starts in defence.
Stefano Sensi and Matias Vecino get the midfield nod, leaving ex-Cagliari local hero Nicolò Barella on the bench.
Barella to all intents and purposes exchanged places with Nainggolan, who left Inter to join Cagliari on loan, making a return to his old club.
It wasn’t the best start, as the Sardinians lost 1-0 at home to newly-promoted Brescia last week, but above all lost hitman Pavoletti for several months to a serious knee injury.
Rolando Maran has to completely revamp his attack and even tactics, considering his central his aerial power was to their success last season.
Instead, Joao Pedro is joined by Alberto Cerri, with an apparent 3-5-2 formation, as Marko Rog returns from suspension with Nahitan Nandez and Luca Pellegrini.
Above all, ex-Roma goalkeeper Robin Olsen is thrown straight into the starting XI, with Giovanni Simeone on the bench.
Alessio Cragno, Fabrizio Cacciatore and Paolo Faragò are also on the treatment table.
Cagliari: Olsen; Pisacane, Ceppitelli, Klavan; Nandez, Rog, Nainggolan, Ionita, Pellegrini; Joao Pedro, Cerri
Cagliari bench: Rafael, Aresti, Pinna, Mattiello, Cigarini, Birsa, Oliva, Lykogiannis, Ragatzu, Castro, Romagna, Simeone
Inter: Handanovic; D’Ambrosio, Ranocchia, Skriniar; Candreva, Vecino, Brozovic, Sensi, Asamoah; Lukaku, Lautaro Martinez
Inter bench: Padelli, Berni, Godin, Gagliardini, Sanchez, Politano, Lazaro, Borja Valero, Dimarco, Barella, Esposito, Bastoni
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