Napoli have Lorenzo Insigne back, but no Arkadiusz Milik or Elseid Hysaj, while Sampdoria miss Jakub Jankto and call up Emiliano Rigoni.
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Carlo Ancelotti has captain Insigne back in the squad, although he is likely to start from the bench after a muscular problem ruled him out of international duty.
Milik and Hysaj are not included in the side, but hope to be available for the Champions League against Liverpool.
Sampdoria give the first call-ups to new arrivals Rigoni and Andrea Seculin, but Ronaldo Vieira is suspended following his red card in the 4-1 defeat to Sassuolo.
Jankto joins Gonzalo Maroni on the treatment table.
Napoli squad: Meret, Ospina, Karnezis, Di Lorenzo, Ghoulam, Koulibaly, Luperto, Maksimovic, Malcuit, Manolas, Mario Rui, Allan, Elmas, Fabian Ruiz, Gaetano, Zielinski, Callejon, Insigne, Llorente, Lozano, Mertens, Younes
Sampdoria squad: Audero, Falcone, Seculin; Augello, Bereszynski, Chabot, Colley, Depaoli, Ferrari, Murillo, Murru, Regini; Barreto, Ekdal, Leris, Linetty, Thorsby; Bonazzoli, Caprari, Gabbiadini, Quagliarella, Ramirez, Rigoni
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