Henrikh Mkhitaryan and Jordan Veretout are expected to start for Roma against Sassuolo in their full Giallorossi debuts.
It kicks off at 17.00 UK time (16.00 GMT), click here for a match preview.
The Giallorossi are still looking for their first win of the season after a 3-3 draw with Genoa and 1-1 result against rivals Lazio.
Coach Paulo Fonseca has new options at his disposal today, as Mkhitaryan arrived on loan from Arsenal on transfer deadline day.
Veretout also arrived from Fiorentina in a deal worth €17m plus bonuses and is tipped to be in the starting XI for his debut this evening.
Cengiz Under, Diego Perotti, Davide Zappacosta and Chris Smalling are all on the treatment table.
Gianluca Mancini is the favourite ahead of Juan Jesus for the centre-back role, while Bryan Cristante is tipped to start rather than Justin Kluivert.
Lorenzo Pellegrini and Nicolò Zaniolo can join Mkhitaryan in supporting centre-forward Edin Dzeko.
Sassuolo have to do without Rogerio and Francesco Magnanelli, while ex-Roma striker Gregoire Defrel should be on the bench, as Jeremie Boga is the favourite to start in the trident attack with Francesco Caputo and Domenico Berardi.
Roma: Pau Lopez; Florenzi, Mancini, Fazio, Kolarov; Veretout, Cristante; Zaniolo, Pellegrini, Mkhitaryan; Dzeko
Sassuolo: Consigli; Muldur, Marlon, Ferrari, Peluso; Duncan, Obiang, Locatelli; Berardi, Caputo, Boga
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