Genoa hope to continue their unbeaten run and find Atalanta distracted by the upcoming Champions League debut, as Andrea Pinamonti and Duvan Zapata face off.
It kicks off at Marassi at 11.30 UK time (10.30 GMT).
You can follow all the build-up and action as it happens from today’s SIX Serie A games on the LIVEBLOG.
The Grifone have had a great start to life under new Coach Aurelio Andreazzoli, fighting back repeatedly for a 3-3 draw at Roma and beating Fiorentina.
Christian Kouame and Andrea Pinamonti are on spectacular form, with former Ajax midfielder Lasse Schone pulling the midfield strings and providing danger from set plays.
Stefano Sturaro and Francesco Cassata are injured, but Cristian Zapata will get to mark his cousin, fellow Colombia international Duvan Zapata.
Atalanta have always stuttered at the start under Gian Piero Gasperini and this season is no different, as they fought back from 2-0 down to beat SPAL 3-2 and lost another goal-packed thriller with Torino.
There is not only the pressure to follow last term’s amazing third-place finish and Coppa Italia Final appearance, but also the added distraction of their first ever Champions League campaign.
They will make their debut away to Dinamo Zagreb on Wednesday and 3,000 fans are making the trip to Croatia.
Timothy Castagne is back on the bench with Rafael Toloi and Marco Sportiello not 100 per cent fit, while Simon Kjaer is in the squad after his deadline day move from Sevilla.
Remo Freuler gets the midfield nod rather than Marten de Roon.
Papu Gomez is in the trequartista role supporting Josip Ilicic and Duvan Zapata, as Luis Muriel is ready to come on as a substitute during the second half.
Atalanta have won six of their last seven Serie A encounters with Genoa, home and away, losing only in this fixture during the 2018-19 season.
They are also unbeaten in seven top flight away matches, so just one shy of their all-time club record set in 1992.
The Orobici are nothing if not entertaining, seeing as in their last six Serie A games, they both scored and conceded.
Genoa: Radu; Romero, C Zapata, Criscito; Ghiglione, Schone, Radovanovic, Lerager, Barreca; Kouame, Pinamonti
Genoa bench: Marchetti, Jandrei, Goldaniga, Sanabria, El Yamiq, Biraschi, Jagiello, Pandev, Favilli, Ankersen, Pajac, Saponara
Atalanta: Gollini; Toloi, Djimsiti, Masiello; Hateboer, Freuler, Pasalic, Gosens; Gomez; Ilicic, Duvan Zapata
Atalanta bench: Rossi, Sportiello, Kjaer, Palomino, Muriel, Arana, De Roon, Malinovskyi, Castagne, Ibañez, Barrow
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/