Lazio rely on Sergej Milinkovic-Savic, Joaquin Correa and Felipe Caicedo in their Europa League opener away to Romanian champions Cluj.
It kicks off at 17.55 UK time (16.55 GMT), you can follow all the action as it happens from this game and Roma-Istanbul Basaksehir on the LIVEBLOG.
Simone Inzaghi has left Ciro Immobile, Luis Alberto and Stefan Radu at home, while Andre Anderson and Jordan Lukaku are not on the UEFA list.
Adam Marusi begins his three-match ban, left over from last season’s dismissal against Sevilla, but Manuel Lazzari and Jony Rodriguez make their all-time UEFA competition debuts.
Denis Vavro and Valon Berisha also get rare starts in a Biancocelesti jersey, as the squad is rotated after falling to a 2-1 defeat to SPAL at the weekend.
Lazio qualified for the Europa League by winning the Coppa Italia in May, but they ended the last campaign with four consecutive UEFA defeats.
CFR Cluj are not to be sniffed at, as they narrowly went out of the Champions League preliminary rounds to Slavia Prague – the side that held Inter to a 1-1 draw at San Siro this week.
They have won the last two Romanian league titles and eliminated Scottish champions Celtic, who are also in this Europa League group along with Rennes, from the Champions League this summer.
Inzaghi said the player he was most concerned at facing is striker Billel Omrani, but he is surprisingly on the bench.
Instead, Cluj move to a 5-3-2 formation with Lacina Traore and Ciprian Deac upfront, as Mario Rondon is injured.
Their Coach is former Genoa, Foggia and Chelsea star Dan Petrescu.
Cluj: Arlauskis; Peteleu, Burca, Boli, Mike, Camora; Bordeianu, Djokovic, Paun; Deac, Traorè
Cluj bench: Fernandez, Pascanu, Luis Aurelio, Omrani, Culio, Susic, Golofca
Lazio: Strakosha; Vavro, Acerbi, Bastos; Lazzari, Milinkovic-Savic, Leiva, Berisha, Jony; Correa, Caicedo
Lazio bench: Proto, Patric, Luiz Felipe, Cataldi, Parolo, Lulic, Adekanye
Ref: Stefanski (POL)