Fernando Llorente and Arkadiusz Milik form an all-new strike partnership for Napoli in their difficult trip to giant-killers Lecce.
It kicks off at 14.00 UK time (13.00 GMT) at the Stadio Via del Mare.
Follow all the build-up and action as it happens from today’s SIX Serie A games on the LIVEBLOG.
Carlo Ancelotti’s men are on Cloud Nine after their midweek 2-0 victory over Champions of Europe Liverpool.
Llorente came off the bench and scored in that game, but he gets his first start in a Napoli jersey here, alongside Milik following his recovery from a muscular problem.
Dries Mertens, Jose Callejon and Hirving Lozano are rested, with a midweek Serie A round coming up, while Kostas Manolas, Allan, Amin Younes and Lorenzo Tonelli are injured.
Carlo Ancelotti makes eight changes from the side that beat Liverpool, including goalkeeper David Ospina,
Lecce caused a huge upset on Monday evening when they beat Torino 2-1 away from home, a side that until then had a 100 per cent record and was about to go joint top of the table with Inter.
Filippo Falco and Marco Mancosu were inspirational and start again today, with ex-Fiorentina striker Khouma Babacar snubbed in favour of Diego Farias.
Panagiotis Tachtsidis is one to watch in midfield, as he can cause problems with his shots from distance.
Lecce: Gabriel; Rispoli, Lucioni, Rossettini, Calderoni; Majer, Tachtsidis, Tabanelli; Mancosu; Falco, Farias
Napoli: Ospina; Malcuit, Maksimovic, Koulibaly, Ghoulam; Elmas, Fabian Ruiz, Zielinski, Insigne; Milik, Llorente
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