Blaise Matuidi and Juan Cuadrado are expected to be the Juventus full-backs in today’s Serie A encounter with SPAL, while Gigi Buffon makes history.
It kicks off at 14.00 UK time (13.00 GMT), click here for a match preview.
The Bianconeri find themselves in an injury crisis, particularly focused around the wide areas of the team, as Mattia De Sciglio, Douglas Costa, Danilo and Giorgio Chiellini are out of action.
Alex Sandro flew back to Brazil on compassionate leave this week following a death in the family, while Mario Mandzukic is still out of the squad even after the failed transfer to Qatar.
Cuadrado has been training as a right-back throughout the summer under Coach Maurizio Sarri, but the shortage of options on the left prompts a radical rethink.
Midfielder Matuidi is expected to take on that role, with Adrien Rabiot stepping in to the more advanced slot.
Cristiano Ronaldo returns from his midweek rest, sending Gonzalo Higuain to the bench instead, with Aaron Ramsey as trequartista.
Gianluigi Buffon is ready to make history with his 903rd Serie A appearance, surpassing the record set by Paolo Maldini at Milan.
SPAL make the trip to Turin without Jasmin Kurtic, Federico Di Francesco, Marco D’Alessandro, Mattia Valoti or Mohamed Fares.
Igor is expected to come into defence with Mirko Valdifiori, who famously worked with Sarri at both Empoli and Napoli, in midfield.
Alberto Paloschi and Sergio Floccari are challenging for the striker role alongside Andrea Petagna.
Juventus: Buffon; Cuadrado, Bonucci, De Ligt, Matuidi; Khedira, Pjanic, Rabiot; Ramsey; Ronaldo, Dybala
SPAL: Berisha; Tomovic, Vicari, Igor; Sala, Murgia, Valdifiori, Jankovic, Reca; Paloschi, Petagna