Napoli are expected the ring the changes again and have a big doubt in defence as they host Mario Balotelli’s Brescia.
It kicks off at 11.30 UK time (10.30 GMT), click here for a match preview.
The Partenopei are fresh from a shock 1-0 home defeat to Cagliari on Wednesday night and need to get back on track to avoid falling away from the top two.
Kalidou Koulibaly was sent off in that midweek round and begins his two-match ban, but Nikola Maksimovic is not fully fit either.
It means Sebastiano Luperto might have to take over at centre-back with Kostas Manolas.
Arkadiusz Milik and Dries Mertens are the favourites to start, but Fernando Llorente and Hirving Lozano are not far behind.
There is also the issue of Piotr Zielinski, who can be used as a midfielder or on the left in place of Lorenzo Insigne, as Carlo Ancelotti embraces squad rotation ahead of the Champions League encounter with Genk.
Brescia are without Ernesto Torregrossa, Emanuele Ndoj and Giangiacomo Magnani, but Balotelli should start despite a slight neck sprain.
It’s a special game for Alfredo Donnarumma, who is from the province of Naples and relishing his debut Serie A season.
If Nicolas Spalek is to be the trequartista, then Romulo and Daniele Dessena are in a tussle for the midfield spot.
Napoli: Ospina; Malcuit, Manolas, Maksimovic, Ghoulam; Callejon, Elmas, Fabian, Insigne; Mertens, Milik
Brescia: Joronen; Sabelli, Cistana, Chancellor, Martella; Bisoli, Tonali, Dessena; Spalek; Balotelli, A Donnarumma
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