Roma face a difficult trip to Lecce’s Stadio Via del Mare with Mkhitaryan, Lorenzo Pellegrini and Edin Dzeko leading the way.
It kicks off at 14.00 UK time (13.00 GMT).
You can follow all the build-up and action as it happens from today’s SIX Serie A games on the LIVEBLOG.
Paulo Fonseca suffered his first defeat on the Giallorossi bench in a midweek 2-0 home loss to Atalanta, so needed to get his men back on track.
Mkhitaryan was rested for that match, but returns to the starting XI in support of Dzeko, while Lorenzo Pellegrini has recovered from a plantar fasciitis issue.
Nicolò Zaniolo is benched in favour of Justin Kluivert, while Amadou Diawara allows Bryan Cristante to rest.
Gianluca Mancini returns from suspension to give Federico Fazio the afternoon off, joining Chris Smalling for his second consecutive match.
Lecce lost both home games this season, but have been surprisingly good for a newly-promoted side with away victories at Torino and SPAL.
Diego Farias, Gianluca Lapadula and Cristian Dell’Orco are out injured, so Khouma Babacar is joined by Filippo Falco and Marco Mancosu upfront.
There’s a starting spot for ex-Roma midfielder Panagiotis Tachtsidis.
Lecce have beaten Roma only twice in Serie A, drawing eight times and losing the other 20.
Lecce: Gabriel; Rispoli, Rossettini, Lucioni, Calderoni; Tachtsidis, Petriccione, Majer; Mancosu; Babacar, Falco
Roma: Pau Lopez; Florenzi, Mancini, Smalling, Kolarov; Diawara, Veretout; Kluivert, Pellegrini, Mkhitaryan; Dzeko
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