Alexis Sanchez and Lautaro Martinez lead the Inter attack at Camp Nou, while Lionel Messi is fit enough to start for Barcelona.
It kicks off at 20.00 UK time (19.00 GMT).
This is the biggest game of the group, but Antonio Conte has to do without star striker Romelu Lukaku due to a muscular problem.
He hasn’t even made the trip to Catalonia, so Lautaro Martinez is partnered by Alexis Sanchez, fresh from a goal and red card on his full Inter Serie A debut.
Diego Godin leads the defence, with Nicolò Barella, Marcelo Brozovic and Stefano Sensi in the centre of midfield.
Antonio Candreva gets the nod rather than the more defensive Danilo D’Ambrosio on the right wing.
Barcelona have more than a few problems to deal with, as their performances in La Liga have been unconvincing and they were held to a draw by Bayer Leverkusen in the Champions League.
Coach Ernesto Valverde is not popular with fans, but has to do without injured Samuel Umtiti, Jordi Alba, teenage sensation Ansu Fati and left-sided winger Junior Firpo, who was a late addition to the absentee list.
Messi has only started one match this season due to recurring muscular issues, but he is passed fit to start with Luis Suarez and Antoine Griezmann.
Ousmane Dembele is also given the opportunity to sit on the bench, as he too is not 100 per cent fit.
Barcelona: Ter Stegen; Sergi Roberto, Piqué, Lenglet, Semedo; Arthur, Busquets, De Jong; Messi, Suarez, Griezmann
Barcelona bench: Neto, Todibo, Dembele, Rakitic, Vidal, Carles Perez, Wague
Inter: Handanovic; Godin, De Vrij, Skriniar; Candreva, Sensi, Barella, Brozovic, Asamoah; Lautaro Martinez, Alexis Sanchez
Inter bench: Padelli, Gagliardini, Vecino, Politano, Esposito, D’Ambrosio, Biraghi
Ref: Skomina (SVN)
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