Romelu Lukaku requires a last-minute fitness test and there are doubts on the right wing for Inter, while Juventus rely on Aaron Ramsey, Cristiano Ronaldo and Gonzalo Higuain.
The Derby d’Italia kicks off at San Siro this evening at 19.45 UK time (18.45 GMT), click here for a match preview.
Antonio Conte faces his former club for the first time and defends his 100 per cent start to the Serie A season in this top of the table Scudetto showdown.
Alexis Sanchez is suspended, but the big question mark is on Lukaku, who missed the midweek 2-1 defeat to Barcelona with a muscular issue.
The Belgian is back in the squad today, but it remains to be seen if he’ll be passed fit to start.
If Lukaku is not available, then the only other alternative is Matteo Politano.
There is one other doubt for Conte, between Danilo D’Ambrosio and Antonio Candreva on the right wing of their 3-5-2 formation.
Diego Godin looks set to revive his decade-long duel with Cristiano Ronaldo, which stretches back through Atletico Madrid-Real Madrid and even Villarreal-Manchester United.
Ronaldo should again be partnered by Higuain rather than Paulo Dybala, with Ramsey returning in the trequartista role after he was rested for the midweek Champions League 3-0 win over Bayer Leverkusen.
Sami Khedira and Blaise Matuidi don’t appear to be letting go of their places around Miralem Pjanic in midfield anytime soon, despite the frustration of Rodrigo Bentancur, Adrien Rabiot and Emre Can.
Maurizio Sarri has precious few choices available to him in defence, as Giorgio Chiellini, Danilo, Mattia De Sciglio, Marko Pjaca and Douglas Costa are injured.
It means Juan Cuadrado at right-back again, a role he has been practicing for all summer, and Alex Sandro on the left.
Matthijs de Ligt is growing into his new Juve career alongside Leonardo Bonucci.
Wojciech Szczesny is expected to start in goal rather than Gianluigi Buffon.
Inter (3-5-2): Handanovic; Godin, De Vrij, Skriniar; D'Ambrosio, Barella, Brozovic, Sensi, Asamoah; R Lukaku, Lautaro Martinez
Inter bench: Padelli, Ranocchia, Bastoni, Biraghi, Lazaro, Dimarco, Borja Valero, Gagliardini, Vecino, Candreva, Politano, Esposito
Juventus (4-3-1-2): Szczesny; Cuadrado, Bonucci, De Ligt, Alex Sandro; Khedira, Pjanic, Matuidi; Ramsey; Higuain, Cristiano Ronaldo
Juventus bench: Buffon, Pinsoglio, Rugani, Demiral, Bentancur, Emre Can, Rabiot, Bernardeschi, Dybala
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