Inter prefer Mauro Icardi to Lautaro Martinez, while Federico Bernardeschi has a new role alongside Cristiano Ronaldo in an experimental Juventus for the Derby d’Italia.
It kicks off at San Siro at 19.30 UK time (18.30 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
Inter prefer Mauro Icardi to Lautaro Martinez, while Federico Bernardeschi has a new role alongside Cristiano Ronaldo in an experimental Juventus for the Derby d’Italia.
It kicks off at San Siro at 19.30 UK time (18.30 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Nerazzurri have plenty to play for, as they have the opportunity to not only consolidate third place, but even potentially close on listless Napoli in second.
There is also the small matter of this being the Derby d’Italia and pride is at stake for both sides, especially as Juve might already have the title sewn up, but they have been crawling along lately.
Luciano Spalletti has Marcelo Brozovic back in midfield after his injury concerns, while Matteo Politano, Radja Nainggolan and Ivan Perisic fan out behind centre-forward Icardi.
It had been widely reported that Lautaro Martinez would again be chosen in attack, but Spalletti has given the former captain a chance to prove himself.
Juventus have few genuine choices available, because Paulo Dybala, Mario Mandzukic, Rodrigo Bentancur, Douglas Costa, Sami Khedira, Martin Caceres and Mattia Perin are all injured.
Bernardeschi therefore takes a new centre-forward role in the 3-5-2 with Cristiano Ronaldo, moving Juan Cuadrado to central midfield.
Giorgio Chiellini makes his comeback after a calf injury to complete the new three-man defence with Leonardo Bonucci and Emre Can in another intriguing experiment.
Inter have not beaten Juve since a 2-1 home result in September 2016, managing only a 0-0 draw and three defeats.
However, the last clean sheet the Bianconeri kept at San Siro was 0-0 in October 2015, conceding four goals in their last two Serie A visits.
Inter: Handanovic; D’Ambrosio, De Vrij, Skriniar, Asamoah; Vecino, Brozovic; Politano, Nainggolan, Perisic; Icardi
Inter bench: Padelli, Gagliardini, Lautaro Martinez, Keita, Ranocchia, Joao Mario, Borja Valero, Cedric Soares, Miranda, Dalbert, Candreva
Juventus: Szczesny; Emre Can, Bonucci, Chiellini; Cancelo, Cuadrado, Pjanic, Matuidi, Alex Sandro; Bernardeschi, Ronaldo
Juventus bench: Pinsoglio, Del Favero, De Sciglio, Barzagli, Kean, Rugani, Matheus Pereira, Spinazzola, Nicolussi Caviglia
Ref: Banti