Romelu Lukaku has recovered to start with Lautaro Martinez, but Juventus surprise with Paulo Dybala and Federico Bernardeschi joining Cristiano Ronaldo.
This top of the table showdown kicks off at the packed San Siro at 19.45 UK time (18.45 GMT).
Antonio Conte faces his former club for the first time and he is protecting a 100 per cent start to the Serie A season with six wins out of six.
They are also yet to concede a goal on home turf in the League this term.
Romelu Lukaku missed the midweek 2-1 Champions League defeat to Barcelona with a muscular problem, but he has fully recovered and partners Lautaro Martinez upfront, especially as Alexis Sanchez is suspended.
Danilo D’Ambrosio gets the nod on the right wing rather than Antonio Candreva, but Kwadwo Asamoah is another ex-Juventus player on the left.
Diego Godin gets to revive his decade-long duel with Cristiano Ronaldo, which started at Villarreal v Manchester United, through Atletico Madrid-Real Madrid and last season’s Champions League.
However, the rest of the attack is full of surprises, as Maurizio Sarri starts Bernardeschi in the trequartista role, with Dybala rather than Gonzalo Higuain.
Aaron Ramsey had been widely expected to start after he was rested for the midweek Champions League 3-0 win over Bayer Leverkusen.
Sarri has precious few choices available to him in defence, as Giorgio Chiellini, Danilo, Mattia De Sciglio, Marko Pjaca and Douglas Costa are injured.
It means Juan Cuadrado at right-back again, a role he has been practicing for all summer, and Alex Sandro on the left.
Inter: Handanovic; Godin, De Vrij, Skriniar; D'Ambrosio, Barella, Brozovic, Sensi, Asamoah; R Lukaku, Lautaro Martinez
Inter bench: Padelli, Ranocchia, Dimarco, Bastoni, Gagliardini, Vecino, Lazaro, Borja Valero, Biraghi, Candreva, Politano, Esposito
Juventus: Szczesny; Cuadrado, Bonucci, De Ligt, Alex Sandro; Khedira, Pjanic, Matuidi; Bernardeschi; Dybala, Cristiano Ronaldo
Juventus bench: Buffon, Pinsoglio, Rugani, Demiral, Bentancur, Emre Can, Rabiot, Higuain, Ramsey
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