Lazio rely on Ciro Immobile and Joaquin Correa in this head-to-head with Atalanta for European places, as Luis Muriel steps in for Duvan Zapata.
It kicks off at 14.00 UK time (13.00 GMT) at the Stadio Olimpico.
You can follow all the build-up and action as it happens from this game, Napoli-Verona and Juventus-Bologna on the LIVEBLOG.
The Biancocelesti need to win games like this to close the gap on the leading group, as Atalanta are in third place after three consecutive Serie A victories.
Lucas Leiva is suspended, so Marco Parolo takes over in midfield, with Correa preferred to Felipe Caicedo as a partner for Immobile.
Manuel Lazzari had been named in the starting XI, but pulled out in the warm-up to make way for Adam Marusic.
Gian Piero Gasperini must do without hitman Duvan Zapata for approximately three weeks after a thigh strain while on international duty with Colombia.
He is replaced by fellow countryman Luis Muriel, with Papu Gomez not given any rest ahead of Tuesday’s Champions League trip to Manchester City.
However, Josip Ilicic is given the afternoon off in favour of Ukraine international Ruslan Malinovskyi, pushing Gomez into a more advanced role.
Gasp realises after two defeats in the group that his focus is squarely on Serie A and getting Atalanta into the top four yet again.
Atalanta have won their last two Serie A meetings with Lazio, but haven’t made it three in a row since 1990.
The clubs did clash more recently in the Coppa Italia Final at the Olimpico back in May, which ended 2-0 for Simone Inzaghi’s Lazio.
Lazio: Strakosha; Luiz Felipe, Acerbi, Radu; Marusic, Milinkovic-Savic, Parolo, Luis Alberto, Lulic; Correa, Immobile
Atalanta: Gollini; Toloi, Palomino, Masiello; Hateboer, Freuler, Pasalic, Gosens; Malinovskyi; Gomez, Muriel
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