Stefano Pioli makes his debut on the Milan bench by hosting Lecce, with Rafael Leao sending Krzysztof Piatek to the bench and Lucas Paqueta in midfield.
It kicks off at San Siro at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Rossoneri sacked Marco Giampaolo after losing four of the opening seven rounds, bringing in former Lazio, Inter and Fiorentina boss Pioli.
Stefano Pioli makes his debut on the Milan bench by hosting Lecce, with Rafael Leao sending Krzysztof Piatek to the bench and Lucas Paqueta in midfield.
It kicks off at San Siro at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Rossoneri sacked Marco Giampaolo after losing four of the opening seven rounds, bringing in former Lazio, Inter and Fiorentina boss Pioli.
It’s an extra special day for the Coach, as it is also his birthday, but there will be no celebratory chants from the crowd, as the ultras in the Curva Sud announced they’ll be on a silent protest throughout.
Davide Calabria and Samu Castillejo are suspended, with Giacomo Bonaventura and Mattia Caldara injured, so Andrea Conti is at right-back and Mateo Musacchio returns from his ban.
Pioli moves to a 4-3-3 formation with Lucas Paqueta and Lucas Biglia in midfield, while misfiring Krzysztof Piatek is benched in favour of Portugal Under-21 international striker Leao in a more central role.
He is flanked by Suso and Hakan Calhanoglu, despite reports that Ante Rebic would get his first start.
Lecce have impressed with their attacking approach and high press following promotion from Serie B, even if the results haven’t always reflected the performances.
Giannelli Imbula is out injured, but Coach Fabio Liverani picks Marco Mancosu as the trequartista supporting Filippo Falco and Khouma Babacar.
There’s a familiar face, as Gabriel was for many years on the Milan books, but joined Lecce as a free agent.
Gianluca Lapadula had a brief spell at San Siro and he is on the Salentini bench.
Lecce have only ever beaten Milan once in 30 Serie A visits to San Siro, 2-1 in October 1997, along with two draws and 12 defeats. They’ve lost their last eight in a row here.
Milan: G Donnarumma; Conti, Musacchio, Romagnoli, Theo Hernandez; Paqueta, Biglia, Kessie; Suso, Leao, Calhanoglu
Milan bench: Reina, A Donnarumma, Bennacer, Piatek, Borini, Rebic, Krunic, Duarte, Gabbia, Rodriguez, Brescianini
Lecce: Gabriel; Meccariello, Lucioni, Rossettini, Calderoni; Tabanelli, Tachtsidis, Majer; Mancosu; Falco, Babacar
Lecce bench: Vigorito, Riccardi, Vera, Petriccione, Benzar, Lapadula, Shakhov, Farias, La Mantia, Rispoli, Lo Faso, Dell’Orco
Ref: Pasqua