Atalanta rely on Josip Ilicic as a False 9 in their trip to Manchester City, where Sergio Aguero, Raheem Sterling and Kevin De Bruyne are the star names.
It kicks off at the Etihad at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens from that game and Juventus-Lokomotiv Moscow on the LIVEBLOG.
Atalanta rely on Josip Ilicic as a False 9 in their trip to Manchester City, where Sergio Aguero, Raheem Sterling and Kevin De Bruyne are the star names.
It kicks off at the Etihad at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens from that game and Juventus-Lokomotiv Moscow on the LIVEBLOG.
You can follow all the build-up and action as it happens from that game and Juventus-Lokomotiv Moscow on the LIVEBLOG.
This is the glamour tie of the group for Gian Piero Gasperini’s men, who are in their first ever Champions League campaign and still seeking their first point.
If the 4-0 defeat to Dinamo Zagreb was painful, they were very unlucky to lose 2-1 with Shakhtar Donetsk to a last-gasp counter-attack.
Perhaps being the underdogs will suit their approach here, but Atalanta must do without injured star centre-forward Duvan Zapata, who suffered a thigh strain on international duty.
His fellow Colombian Luis Muriel was expected to step in, supported by Ilicic and captain Papu Gomez.
Instead, Ilicic is moved into a False 9 role, with Gomez and Ruslan Malinovskyi giving the opposition defence few reference points.
Jose Luis Palomino and Simon Kjaer are also not fully fit, so Andrea Masiello starts in defence with Rafael Toloi and Berat Djimsiti.
Manchester City are the undoubted favourites to win this group and one of the main contenders to take the trophy at the end of the season, having spent huge sums on the transfer market over the last few years.
Joao Cancelo is surprisingly benched in favour of Kyle Walker, with Rodri and Fernandinho two midfielders used as centre-backs, despite the fact Nicolas Otamendi and John Stones are available again.
It means 19-year-old Phil Foden is started in midfield, where he scored against Dinamo Zagreb after coming off the bench in the final minute.
De Bruyne pulls the midfield strings, with Riyad Mahrez, Sterling and Kun Aguero upfront.
They have won both Champions League games so far, scoring five goals and conceding zero.
They have won each of their last five continental home matches.
Oleksandre Zinchenko, Aymeric Laporte and Leroy Sane are out of action, with Gabriel Jesus ready to come off the bench and add more firepower.
Nicolas Otamendi, Kyle Walker and John Stones are available again.
Approximately 2,500 fans have made the journey from Bergamo to be here for an historic occasion.
Manchester City: Ederson; Walker, Fernandinho, Rodri, Mendy; De Bruyne, Foden, Gundogan; Mahrez, Aguero, Sterling
Man City bench: Bravo, Stones, Gabriel Jesus, Bernardo Silva, David Silva, Cancelo, Otamendi
Atalanta: Gollini; Toloi, Djimsiti, Masiello; Castagne, Freuler, De Roon, Gosens; Gomez, Malinovskyi; Ilicic
Atalanta bench: Sportiello, Muriel, Arana, Hateboer, Ibanez, Pasalic, Barrow
Ref: Grinfeld (ISR)