Davide Santon is also out of action for Roma’s Europa League match with Borussia Monchengladbach, adding to the extensive injury crisis.
It kicks off on Thursday at 17.55 UK time (16.55 GMT).
The Giallorossi were already without Cengiz Under, Henrikh Mkhitaryan, Lorenzo Pellegrini, Amadou Diawara, Bryan Cristante and Nikola Kalinic.
Santon was going to be repurposed for a midfield role, but the full-back won’t be participating either, as he is struggling with flu symptoms.
Coach Paulo Fonseca hinted he could even be forced to change tactical system to deal with the absentees.
Roma squad for Borussia Monchengladbach: Pau Lopez, Cardinali, Mirante; Juan Jesus, Smalling, Kolarov, Fazio, Mancini, Florenzi, Spinazzola, Calafiori; Perotti, Veretout, Zaniolo, Pastore, Riccardi; Dzeko, Antonucci, Kluivert
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