Napoli can close on the top two, but face a difficult trip to Andrea Petagna’s SPAL, as Arkadiusz Milik and Lorenzo Insigne return.
It kicks off at the Stadio Paolo Mazza at 14.00 GMT.
You can follow all the build-up and action as it happens from today’s SIX Serie A games on the LIVEBLOG.
The Partenopei are fresh from a thrilling 3-2 midweek victory away to RB Salzburg in the Champions League, decided by a Dries Mertens brace and Insigne off the bench.
Carlo Ancelotti rings the changes again, as Insigne and Milik step into the starting XI, replacing Hirving Lozano and Fabian Ruiz, while Eljif Elmas comes in for Jose Callejon and Piotr Zielinski moves to the centre.
Kostas Manolas, Nikola Maksimovic, Mario Rui and Elseid Hysaj are still carrying injuries, so Sebastiano Luperto is again in defence.
SPAL are in penultimate place with just six points, but all those were earned on home turf, beating Lazio and Parma.
Federico Di Francesco, Marco D’Alessandro, Marko Jankovic and Mohamed Fares are still on the treatment table.
The star man is ex-Atalanta centre-forward Petagna, with support from Alberto Paloschi and Alessandro Murgia, plus lively winger Gabriel Strefezza.
SPAL: Berisha; Tomovic, Vicari, Igor; Strefezza, Missiroli, Murgia, Kurtic, Reca; Paloschi, Petagna
Napoli: Ospina; Malcuit, Koulibaly, Luperto, Di Lorenzo; Elmas, Allan, Zielinski, Insigne; Milik, Mertens
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