Roma give Mert Cetin his first start in a revamped defence, as they host Kostas Manolas and Napoli in a head-to-head for fourth place.
It kicks off at the Stadio Olimpico at 14.00 GMT.
You can follow all the build-up and action as it happens from this game, Bologna-Inter and Torino-Juventus on the LIVEBLOG.
There is only one point separating these two teams going into the weekend, with Lazio and surprisingly Cagliari also challenging for fourth place.
Federico Fazio is suspended following his controversial red card against Udinese, a game Roma went on to win 4-0 anyway on Wednesday evening.
He joins the long list of players on the treatment table, such as Lorenzo Pellegrini, Bryan Cristante, Amadou Diawara, Henrikh Mkhitaryan, Nikola Kalinic and Davide Zappacosta.
It means Mert Cetin gets his first start in a Giallorossi jersey at the centre of defence, while Gianluca Mancini remains in a more advanced midfield role to fill the gaps.
Edin Dzeko is the only choice as centre-forward, with support from Justin Kluivert, Javier Pastore and Nicolò Zaniolo.
Napoli had their own furious response to contentious refereeing in the midweek round, as they had penalty appeals rejected when Atalanta went up the other end and scored for a 2-2 draw.
Carlo Ancelotti was sent off for his protests and is therefore in the stands for this match, as his appeal against a touchline ban was turned down this morning.
Kevin Malcuit is out for six months following knee surgery, with Allan sidelined for around four weeks with a sprained knee.
The good news is that Kostas Manolas returns from injury to face his former club, with Mario Rui also back in action, but Elseid Hysaj is still struggling with a fractured sternum.
Piotr Zielinski steps in for Allan, while the race for a front two spot is won by Arkadiusz Milik and Dries Mertens, with Lorenzo Insigne and Jose Callejon on the wings.
Mertens was the expected choice, considering he has scored five goals in his last five games against the Giallorossi.
Napoli have a very strong recent record against Roma, winning their last three Serie A visits to the Olimpico.
Roma: Pau Lopez; Spinazzola, Cetin, Smalling, Kolarov; Veretout, Mancini; Zaniolo, Pastore, Kluivert; Dzeko
Roma bench: Fuzato, Mirante, Juan Jesus, Perotti, Under, Santon, Florenzi, Antonucci
Napoli: Meret; Di Lorenzo, Manolas, Koulibaly, Mario Rui; Callejon, Zielinski, Fabian Ruiz, Insigne; Milik, Mertens
Napoli bench: Ospina, Karnezis, Llorente, Lozano, Elmas, Luperto, Maksimovic, Hysaj, Younes, Tonelli, Gaetano
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