Atalanta bring Luis Muriel back into the starting XI with Josip Ilicic and Papu Gomez against Cagliari’s Radja Nainggolan and Giovanni Simeone.
It kicks off at the Gewiss Stadium in Bergamo at 11.30 GMT.
You can follow the build-up and action as it happens from today’s SIX Serie A games on the LIVEBLOG.
Gian Piero Gasperini’s men shattered records last season and are eager to do even better this time around, feeling full of confidence after a 7-1 win over Udinese and controversial 2-2 midweek draw with Napoli.
Squad rotation is largely snubbed ahead of a Champions League meeting with Manchester City, so Papu Gomez, Luis Muriel and Josip Ilicic all start.
Duvan Zapata is still out of action and Marten De Roon is suspended.
Cagliari are hoping to be the New Atalanta, as they too have a squad packed with talent eager to make their mark in the race for Europe.
Nainggolan is the star attraction, although Simeone has also started finding his shooting boots since the move from Fiorentina.
Valter Birsa and Luca Ceppitelli joined long-term absentees Alessio Cragno and Leonardo Pavoletti on the treatment table, with full-back Luca Pellegrini sitting out a ban.
Nahitan Nandez is rested following an injury scare, so Lucas Castro and Christian Oliva and Marko Rog pull the midfield strings.
These teams haven’t played a draw since the 1-1 in Bergamo in January 2013, followed by six Atalanta victories and five for Cagliari between Serie A and the Coppa Italia.
Atalanta: Gollini; Toloi, Palomino, Djimsiti; Castagne, Pasalic, Freuler, Gosens; Gomez; Ilicic, Muriel
Atalanta bench: Rossi, Sportiello, Kjaer, Masiello, Arana, Malinovskyi, Hateboer, Ibanez, A Traore, Barrow
Cagliari: Olsen; Cacciatore, Pisacane, Klavan, Lykogiannis; Castro, Oliva, Rog; Nainggolan; Joao Pedro, Simeone
Cagliari bench: Rafael, Aresti, Pinna, Mattiello, Cigarini, Cerri, Nandez, Ionita, Faragò, Ragatzu, Deiola, Walukiewicz
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