Sampdoria drop Fabio Quagiiarella for Federico Bonazzoli against SPAL, who also make a change up top.
Quagliarella’s failure to hit the heights of last season means Claudio Ranieri will go with Bonazzoli.
The 22-year-old began his career at Inter and was prolific for Italy at various youth levels.
However, he has managed just 12 competitive goals since making his senior debut in 2015.
Elsewhere, Alex Ferrari, Morten Thorsby and Albin Ekdal come in for Jeison Murillo, Mehdi Leris and Andrea Bertolacci.
SPAL, meanwhile, give youngster Gabriele Moncini a run-out alongside target man Andrea Petagna, who has just one goal in his last six games.
There are also places for Igor at the back and Mattia Valoti in central midfield.
The Paolo Mazza tonight plays host to Serie A’s two bottom clubs in the Biancazzurri and Samp.
SPAL: Berisha; Tomovic, Vicari, Igor; Espeto, Valoti, Murgia, Kurtic, Reca; Petagna, Moncini
Sampdoria: Audero; Berezynski, Ferrari, Colley, Murru; Thorsby, Vieira, Ekdal, Jankto; Gabbiadini, Bonazzoli
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