Matthijs de Ligt is out of the Juventus squad travelling to Lokomotiv Moscow for the Champions League game due to a sprained ankle.
It kicks off on Wednesday at 17.55 GMT, valid for the group stage of the tournament.
Defender De Ligt has not made the trip, as he sprained his left ankle during the victory over Torino on Saturday, where he scored the winner.
It is only a light sprain and he should be available for this weekend’s Serie A clash with Milan.
The candidates to replace the Dutchman are Daniele Rugani and Merih Demiral.
Giorgio Chiellini is a long-term absentee, while Emre Can and Mario Mandzukic are not in the UEFA list.
Juventus squad for Lokomotiv Moscow: Szczesny, De Sciglio, Pjanic, Khedira, Ronaldo, Ramsey, Dybala, Douglas Costa, Alex Sandro, Danilo, Matuidi, Bonucci, Higuain, Rugani, Rabiot, Demiral, Bentancur, Pinsoglio, Bernardeschi, Buffon
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/