Juventus have Paulo Dybala, Mario Mandzukic and Leonardo Spinazzola back, but Milan reshuffle with Fabio Borini, Suso and Krzysztof Piatek.
It kicks off in Turin at 17.00 UK time (16.00 GMT).
You can follow the build-up and action as it happens and give your views on the LIVEBLOG.
Juventus have Paulo Dybala, Mario Mandzukic and Leonardo Spinazzola back, but Milan reshuffle with Fabio Borini, Suso and Krzysztof Piatek.
It kicks off in Turin at 17.00 UK time (16.00 GMT).
You can follow the build-up and action as it happens and give your views on the LIVEBLOG.
The Bianconeri could even win their eighth consecutive Scudetto this weekend, as if they beat Milan and Napoli lose to Genoa, they will be mathematically out of reach.
Max Allegri receives a boost with the return of Dybala, Mandzukic and Spinazzola, while Mattia De Sciglio starts in a three-man defence against his old club, allowing Giorgio Chiellini to rest.
Cristiano Ronaldo, Martin Caceres, Andrea Barzagli, Douglas Costa, Juan Cuadrado and Mattia Perin are out injured.
Miralem Pjanic also rests in midfield, giving Federico Bernardeschi a more central role.
Milan have bigger issues to deal with, as Gianluigi Donnarumma and Lucas Paqueta limped off during the 1-1 draw with Udinese midweek and are out of action.
Hakan Calhanoglu pulled up in training yesterday, but is still passed fit to start with the returning Franck Kessie.
Suso was rested against Udinese, but the 4-3-1-2 experiment is shelved with Paqueta’s injury, so the Spaniard and Borini flank Piatek rather than Samu Castillejo.
It is Borini’s first Serie A start since January 21 against Genoa, where he scored.
The pressure is piling on Gennaro Gattuso, because one point from the last three rounds means Atalanta have been able to close the gap to just one point in a battle royal for Champions League places.
Milan have a famously awful record in Turin, losing their last seven Serie A visits on the bounce.
Incredibly, the most recent victory was 1-0 in March 2011, decided by a Gattuso goal with Max Allegri on the Milan bench.
Juventus: Szczesny; De Sciglio, Bonucci, Rugani; Spinazzola, Bernardeschi, Emre Can, Bentancur, Alex Sandro; Dybala, Mandzukic
Juventus bench: Pinsoglio, Chiellini, Khedira, Cancelo, Matuidi, Pjanic, Kean, Del Favero, Matuidi, Nicolussi Caviglia
Milan: Reina; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Bakayoko, Calhanoglu; Suso, Piatek, Borini
Milan bench: A Donnarumma, Soncin, Abate, Caldara, Laxalt, Strinic, Zapata, Bertolacci, Biglia, Mauri, Castillejo, Cutrone
Ref: Fabbri