Cristiano Ronaldo and Matthijs de Ligt start for Juventus, as Gonzalo Higuain faces his old club Milan, who welcome back Suso.
It kicks off in Turin at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
The Bianconeri need a victory to recapture the Serie A leadership after Inter beat Verona 2-1 on Saturday.
Only Giorgio Chiellini remains as the long-term absentee, because Ronaldo picked up a muscular issue during the 2-1 Champions League win at Lokomotiv Moscow and De Ligt missed that trip entirely due to a sprained ankle.
Both are passed fit to start here this evening, with Higuain facing the club where he spent six less than impressive months on loan last year.
Federico Bernardeschi returns to the starting XI in the trequartista role and Juan Cuadrado is back after he missed Moscow through suspension.
Milan are without Mateo Musacchio, Samu Castillejo and Fabio Borini, while Franck Kessie was left behind due to a poor attitude and form.
Stefano Pioli had tested a 3-4-2-1 formation in training, but sticks to the 4-3-3 today with Andrea Conti rather than Davide Calabria at right-back, while Leo Duarte replaces Musacchio in central defence.
Ismael Bennacer and Rade Krunic again take the midfield reins with Lucas Paqueta.
Suso is back after his hip issue, completing the trident with Krzysztof Piatek and Hakan Calhanoglu.
The last time Milan beat Juventus in Turin in the league was back in 2011, when Gennaro Gattuso scored the only goal.
Juventus: Szczesny; Cuadrado, Bonucci, De Ligt, Alex Sandro; Bentancur, Pjanic, Matuidi; Bernardeschi; Higuain, Cristiano Ronaldo
Juventus bench: Pinsoglio, Buffon, De Sciglio, Khedira, Ramsey, Dybala, Douglas Costa, Danilo, Emre Can, Rugani, Rabiot, Demiral
Milan: G Donnarumma; Conti, Duarte, Romagnoli, Theo Hernandez; Paqueta, Bennacer, Krunic; Suso, Piatek, Calhanoglu
Milan bench: Reina, A Donnarumma, Calabria, Bonaventura, Leao, Rebic, Biglia, Caldara, Gabbia, Rodriguez
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