Italy look to Andrea Belotti, Federico Bernardeschi, Lorenzo Insigne and Sandro Tonali for their Euro 2020 trip to Edin Dzeko and Miralem Pjanic’s Bosnia and Herzegovina.
It kicks off in Zenica at 19.45 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
The Azzurri have already qualified for Euro 2020 with a 100 per cent record in this group, but have plenty of motivation to keep the run going.
They need points to lock down a top seed status in the draw for the European Championship, as well as the 2022 World Cup qualifying campaign.
Roberto Mancini can also make history as the first Italy coach ever to put together 10 consecutive victories.
Several players pulled out with injuries, including Marco Verratti, Giorgio Chiellini, Domenico Berardi, Leonardo Spinazzola and most recently Gianluca Mancini.
That means Francesco Acerbi gets the nod at centre-back with Leonardo Bonucci, while Brescia starlet Tonali gets only his second senior cap in a midfield with Jorginho and his former Under-21 international teammate Nicolò Barella.
Andrea Belotti of Torino leads the attack, flanked by Federico Bernardeschi and Lorenzo Insigne.
Alessandro Florenzi can't get playing time at Roma, but starts at right-back here.
Bosnia and Herzegovina are practically out of the running for a place at Euro 2020, but the Federation rejected Robert Prosinecki’s offer of resignation in September, so he remains at the helm.
Roma striker Edin Dzeko leads the attack with Juventus midfielder Miralem Pjanic and new Milan signing Rade Krunic also featuring.
Edin Visca earns his 50th cap, having scored 10 goals, because Amer Gojak pulled out with an injury.
Bosnia are unbeaten in seven home fixtures, winning five and drawing two since the 4-3 thriller with Belgium in October 2017.
However, the Bilino Polje Stadium in Zenica is a lucky charm for this team, unbeaten here since September 2014 with 10 victories and four draws, scoring 37 goals and conceding six, with 10 clean sheets.
Bosnia-Herzegovina: Sehic; Krvzic, Kovacevic, Bicakcic, Kolasinac; Pjanic, Besic, Cimirot, Krunic; Visca, Dzeko
Bosnis bench: Buric, Piric, Civic, Hotic, Duljevic, Hajradinovic, Ar Hodzic, Mihojevic, Memisevic, I Hajrovic, Saric, Jajalo
Italy: G Donnarumma; Florenzi, Bonucci, Acerbi, Emerson Palmieri; Tonali, Jorginho, Barella; Bernardeschi, Belotti, Insigne
Italy bench: Sirigu, Gollini, Di Lorenzo, Biraghi, Izzo, Zaniolo, Romagnoli, Chiesa, Mandragora, Immobile, El Shaarawy, Castrovilli
Ref: Scharer (SUI)
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