UEFA have assigned Portuguese referee Tiago Martins to take charge of Italy's game against Armenia on Monday at the Stadio Renzo Barbera.
Martins will be assisted by Ferreira Pinto Campos, Mota Almeida and the fourth official will be Carvalho Nobre.
The 39-year-old has only officiated one Italy game, in a 1-1 draw with Macedonia in a World Cup qualifier in October 2017.
He has also took charge of a single game involving Roma, another draw in this season's Europa League against Wolfsberger.
It will be the first time he has crossed paths with Armenia.
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