Atalanta miss several key players in attack, so rely on Papu Gomez and Musa Barrow as they host leaders Juventus with Paulo Dybala and Gonzalo Higuain.
It kicks off at the Gewiss Stadium in Bergamo at 14.00 GMT.
You can follow the build-up and action as it happens from this game, Milan-Napoli and Torino-Inter on the LIVEBLOG.
Gian Piero Gasperini’s men avoided defeat in all three encounters with Juve last season, drawing twice in Serie A and crushing the reigning trophy holders 3-0 in the Coppa Italia quarter-final.
However, Juve haven’t lost to La Dea in Serie A since February 2001, emerging with 23 wins and six draws.
They are once again pushing to finish in the Champions League places, although they have had difficulties juggling both tournaments.
Josip Ilicic and Ruslan Malinovskyi are suspended, but Duvan Zapata is still not even in the squad over six weeks after his serious thigh injury in Colombia.
He scored seven goals in nine competitive games before that setback and they’ve never quite been the same without him.
Luis Muriel is not 100 per cent fit either after returning late from international duty with Colombia.
Papu Gomez and Mario Pasalic therefore support Musa Barrow, who turned 21 only last week and has only four Serie A goals in 38 appearances.
This is his first start since a 6-2 victory away to Sassuolo in December 2018.
Juventus have left Cristiano Ronaldo at home to recuperate after reaching 99 goals for Portugal.
Alex Sandro and Giorgio Chiellini are also out of action, so Mattia De Sciglio shifts over to left-back, but Miralem Pjanic is fit to start despite a muscular issue on international duty with Bosnia and Herzegovina.
Aaron Ramsey scored twice to help Wales reach Euro 2020, but is rested in favour of Federico Bernardeschi as the trequartista behind Gonzalo Higuain and Paulo Dybala.
Atalanta: Gollini; Toloi, Palomino, Djimsiti; Hateboer, De Roon, Freuler, Gosens; Gomez, Pasalic; Barrow
Atalanta bench: Rossi, Sportiello, Kjaer, Masiello, Muriel, Arana, Piccoli, Da Riva, Castagne, Ibanez, Traore, Colley
Juventus: Szczesny; Cuadrado, Bonucci, De Ligt, De Sciglio; Khedira, Pjanic, Bentancur; Bernardeschi; Higuain, Dybala
Juventus bench: Pinsoglio, Buffon, Ramsey, Douglas Costa, Danilo, Matuidi, Emre Can, Rugani, Demiral
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