Lorenzo Pellegrini starts for Roma against Istanbul Basaksehir this evening, with Nikola Kalinic and Henrikh Mkhitaryan among the substitutes.
Pellegrini is given the role of No 10, providing the ammunition behind lone striker Edin Dzeko.
Elsewhere, Leonardo Spinazzola is back in the squad after a spell out injured, but Davide Santon is preferred at right-back.
Spinazzola is joined on the bench by Kalinic and Mkhitaryan, both of whom are welcome returns for coach Paulo Fonseca.
Basaksehir, meanwhile, line up with former Arsenal and Manchester City left-back Gael Clichy.
They can also call on ex-Milan star Robinho and Barcelona old boy Arda Turan during the match.
Roma thrashed the Turkish side 4-0 back in September but have not won in the Europa League since.
The fixture also sees Cengiz Under return to his former stomping ground for the first time in Giallorosso.
Istanbul Basaksehir: Mert; Ponck, Skrtel, Epureanu, Clichy; Azubuiki, Mehmet, Irfan; Visca, Crivelli, Gulbrandsen
Subs: Volkan, Arda, Ba, Behich, Berkay, Robinho, Aleksic
Roma: Pau Lopez; Santon, Mancini, Smalling; Kolarov; Diawara, Veretout; Zaniolo, Pellegrini, Kluivert; Dzeko
Subs: Fuzato, Perotti, Cengiz, Kalinic, Fazio, Spinazzola, Mkhitaryan
Referee: Hategan (ROM)
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