Bobby Adekanye makes a rare start against CFR Cluj for Lazio, who are without Ciro Immobile and Sergej Milinkovic-Savic.
Lazio have to make up six points in their final two Europa League group games to stand any chance of reaching the last 32.
However, they do not seem at all concerned about progressing as their two talisman are left out completely, as is goalkeeper Thomas Strakosha.
That gives Adekanye – a summer signing from Liverpool – a chance to stake his claim up top, the 20-year-old without a goal after just two substitute appearances.
Cluj beat the Aquile 2-1 away from home when the sides last met, and they only need a draw to confirm their passage into the knockout stages.
Lazio: Proto; Bastos, Vavro, Acerbi; Lazzari, Parolo, Cataldi, Luis Alberto, Jony; Adekanye, Correa
Subs: Patric, Lulic, Luiz Felipe, Caicedo, Falbo, Alia, Guerrieri
CFR Cluj: Arlauskis; Cestor, Boli, Burca, Camora; Bordeianu, Djokovic, Culio; Peteleu, Omrani, Paun
Subs: Golofca, Deac, Pascanu, Traore, Jesus Fernandez, Susic, Hoban
Referee: Palabiyik (TUR)
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