Brescia have Mario Balotelli back in the starting XI, sending Alfredo Donnarumma to the bench, as Atalanta look to Luis Muriel in this bitter grudge match.
It kicks off at the Stadio Rigamonti at 14.00 GMT.
You can follow all the action as it happens from this game, Genoa-Torino and Fiorentina-Lecce on the LIVEBLOG.
These two clubs are bitter rivals going back decades and it is their first Serie A encounter since April 2005.
Balotelli was dropped from the squad last week following a training ground bust-up with coach Fabio Grosso, but he is straight back in the starting XI with Ernesto Torregrossa at the expense of Alfredo Donnarumma.
Daniele Dessena is on the treatment table for at least another six weeks, but Grosso otherwise has a full squad to choose from, including Italy international midfielder Sandro Tonali.
Grosso moves to a 3-5-2 formation with Romulo in a more central midfield role.
Atalanta are fresh from their first ever Champions League victory, beating Dinamo Zagreb 2-0 at San Siro midweek, and are still in with a chance of reaching the Round of 16.
Rafael Toloi is suspended in defence with Simon Kjaer and Duvan Zapata injured, so the defence is down to the bare bones.
Josip Ilicic returns from his two-match ban to lead the attack with Papu Gomez and Luis Muriel, pushing Mario Pasalic into midfield.
Brescia: Joronen; Mangraviti, Chancellor, Cistana; Sabelli, Ndoj, Tonali, Romulo, Martella; Balotelli, Torregrossa
Atalanta: Gollini; Masiello, Djimsiti, Palomino; Castagne, De Roon, Pasalic, Gosens; Ilicic, Gomez; Muriel
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