Fiorentina miss Federico Chiesa again, so Dusan Vlahovic partners Franck Ribery, while Lecce drop Khouma Babacar against his old club.
It kicks off at 19.45 GMT, you can follow all the action as it happens on the LIVEBLOG.
The Viola are back in crisis mode after one point from three rounds, conceding nine goals in their last five Serie A games, including a 5-2 defeat to Cagliari.
Chiesa is still out of action with injury, so Vlahovic starts upfront with Ribery, while Federico Ceccherini fills in for captain German Pezzella, who fractured his cheekbone and is out for three weeks.
The good news for Vincenzo Montella is the return of Gaetano Castrovilli and Erick Pulgar from suspension, as they were sorely missed in the 1-0 loss to Hellas Verona.
They are up against another surprisingly impressive newly-promoted club this evening, as Lecce have just one defeat in the last six rounds, including draws with Milan, Juventus and Cagliari.
The Salentini fought back from 2-0 down to hold Cagliari 2-2 last week, but Gianluca Lapadula was sent off and is therefore suspended.
Zan Majer, Filippo Falco, Marco Mancosu, Biagio Meccariello and Luka Dumancic are injured, so it was assumed Babacar would start against his old club.
Instead, Andrea La Mantia gets the nod with Diego Farias.
Fiorentina: Dragowski; Milenkovic, Ceccherini, Caceres; Lirola, Castrovilli, Badelj, Pulgar, Dalbert; Ribery, Vlahovic
Lecce: Gabriel; Rispoli, Lucioni, Rossettini, Calderoni; Petriccione, Tachtsidis, Tabanelli; Shakhov; Farias, La Mantia
Watch Serie A live in the UK on Premier Sports for just £9.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/