Cristiano Ronaldo returns to the starting XI with Gonzalo Higuain, as Juventus host a Sassuolo side with an 18-year-old debutant in goal.
It kicks off at the Allianz Juventus Stadium in Turin at 11.30 GMT.
The Bianconeri are top of the Serie A table and still unbeaten in all competition, but remain under pressure from Inter.
Sami Khedira has joined the absentee list with a knee issue, so is out of action with Douglas Costa, Adrien Rabiot and Giorgio Chiellini.
It’s an opportunity for Emre Can to get a run-out in midfield with Miralem Pjanic and Rodrigo Bentancur.
Federico Bernardeschi returns for the trequartista role, with Ronaldo partnering Higuain, sending midweek Champions League hero Paulo Dybala to the bench.
Sassuolo’s results have not reflected the standard of their performances so far this season, as their leaky defence has caused problems.
Coach Roberto De Zerbi plays a similar style of football to Maurizio Sarri, with quick passing and possession, but he is without injured Domenico Berardi, Gregoire Defrel, Gian Marco Ferrari, Gianluca Pegolo and Vlad Chiriches.
The big news is that Andrea Consigli isn’t fully fit either, so 18-year-old Stefano Turati is thrown into the starting XI for his senior Sassuolo debut.
It means Francesco Caputo leads the trident attack with Filip Djuricic and very pacey Jeremy Boga, with former Juve youth academy product Filippo Romagna in defence.
Sassuolo have a famously dreadful record at the Juventus Stadium, losing all six Serie A visits, scoring two goals and conceding 18. That includes a 7-0 result here in February 2018, with Higuain hat-trick.
Home and away, the Neroverdi have suffered seven consecutive league defeats to Juve.
Juventus: Buffon; Cuadrado, Bonucci, De Ligt, Alex Sandro; Emre Can, Pjanic, Bentancur; Bernardeschi; Higuain, Ronaldo
Sassuolo: Turati; Toljan, Marlon, Romagna, Kyriakopoulos; Magnanelli, Traore, Locatelli; Djuricic, Caputo, Boga
Ref: La Penna
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