Napoli have Lorenzo Insigne back with Chucky Lozano and Fernando Llorente, resting Dries Mertens, as they host Rodrigo Palacio’s Bologna.
It kicks off at the Stadio San Paolo at 17.00 GMT.
Carlo Ancelotti got Napoli at least slightly back on track with a 1-1 Champions League draw at Liverpool midweek and he drops Jose Callejon once again.
Insigne returns after an elbow injury and is pushed to the wing of a 4-4-2 once more, with Lozano partnered by Llorente.
Allan is out after hurting his ribs during the Liverpool game, so Eljif Elmas and Piotr Zielinski take the midfield roles.
Arkadiusz Milik, Kevin Malcuit, Faouzi Ghoulam and Lorenzo Tonelli are also injured.
Considering Nikola Maksimovic’s presence, it’s possible this is almost a three-man defence.
Bologna have struggled in the absence of coach Sinisa Mihajlovic during his treatment for leukaemia.
He was released from hospital this week following a bone marrow transplant, but is not yet well enough to sit on the bench at the Stadio San Paolo.
Federico Santander, Roberto Soriano and Mitchell Dijks are out of action, so Riccardo Orsolini, Rodrigo Palacio and Nicola Sansone make up the trident attack.
Napoli: Ospina; Maksimovic, Manolas, Koulibaly, Di Lorenzo; Fabian Ruiz, Zielinski, Elmas, Insigne; Lozano, Llorente
Bologna: Skorupski; Tomiyasu, Bani, Danilo, Denswil; Dzemaili, Medel, Poli; Orsolini, Palacio, Sansone
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/